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Precision insights for better outcomes in implant surgery

Supporting decision making in implant surgery through next-generation patient diagnostics, and pioneering explant analysis

Screen

Prior to surgery, screen patients to ensure the most appropriate choice of implant material.

Investigate

For patients experiencing issues with their implants test to check for possible loosening and/or reactions to implant materials.

Analyse

Following revision of problem implants have them analysed to identify potential reasons for failure and presence of pathogens.

At ExplantLab we offer tests and services to support surgeons and their patients from pre-surgical screening, through investigation of issues with poorly performing implants and ultimately bioengineering explant analysis and pathogen screening of failed implants that have been revised.

Screen

Pre-operative genetic screening to quantify a patient’s risk of a poorer clinical outcome due to developing a reaction to implant materials.

Approximately 15% to 21% of patients carry genes that increase the risk of having a poorer surgical outcome with certain implant materials

The test was easy to do at home, and I sent it back in the post. A couple of weeks later I learned that I have the genes that might make me more likely to react badly to the most commonly used knee replacement implants. Having this information is empowering because my doctor can use it to choose the best kind of implant for me, which makes me feel a lot more confident about having the surgery.

Sally

Knee Replacement Patient

Simplified at-home pre-operative genetic test to identify a patient’s gross risk factors for a poorer clinical outcome due to developing a reaction to implant materials.

Investigate

Identification of wear and loosening in poorly performing implants with a titanium component

Waiting times for CT and bone scans scans, and delays in reporting are a challenge in many trusts (Royal College of Radiology).Fric[Ti]on can provide insights in to implant performance before scans are even scheduled and can avoid patients’ exposure to radiation.

Studies consistently show that 10 to 25% of patients who receive a joint replacement may develop chronic pain.There is an increasing amount of evidence to indicate poor clinical outcomes may be due to adverse immune responses to cobalt chrome.Histologically confirmed signs of delayed type metal allergy (ALVAL) have been identified in between 7 and 44% patients undergoing revision of their TKRs.

Investigation of poorly performing implants combining genetic screening and identification of wear/loosening.

Analyse

Explant analysis available at a previously unattainable price point.

Developments in automation, processes innovation and creation of validated, peer reviewed analysis methods have enabled us to now make explant analysis available at a previously unattainable price point.
Our service enables surgeons and hospitals to access a fast, cost effective analysis service providing expert explant reports.

BOA Quote?

Pathogen detection?

ExplantLab are the national service provider to the NHS Implant Analysis Service.
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We work directly with hospital trusts across the UK to provide fast, accurate and cost effective explant analysis.